RT Journal Article
SR Electronic
T1 Small Leucine Rich Proteoglycans Are Differently Distributed in Normal and Pathological Endometrium
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 217
OP 222
VO 29
IS 2
A1 ANGELA LUCARIELLO
A1 ELISABETTA TRABUCCO
A1 OLGA BOCCIA
A1 ANGELICA PERNA
A1 CARMINE SELLITTO
A1 MARIA A. CASTALDI
A1 MARIA DE FALCO
A1 ANTONIO DE LUCA
A1 LUIGI COBELLIS
YR 2015
UL http://iv.iiarjournals.org/content/29/2/217.abstract
AB Background: During the woman's fertile period, the non-pregnant uterus is subject to constant cyclic changes. The complex mechanisms that control the balance among proliferation, differentiation, cell death and the structural remodeling of the extracellular matrix can contribute to the benign or malignant endometrial pathological state. The small leucine-rich proteoglycans (SLRPs) are important components of cell surface and extracellular matrices. Materials and Methods: Using immunohistochemistry, we showed that the distribution patterns of SLRPs were completely modified in the pathological compared to normal endometrium. Results: The expression of SLRPs was low/absent in all endometrial pathologies examined compared to normal endometrium. We observed an increase of lumican from proliferative to secretory phase of the endometrium and a decrease of fibromodulin, biglycan and decorin. In menopause endometrial tissue, the level of expression of fibromodulin, biglycan, decorin and lumican dramatically decreased. Conclusion: The results revealed the prominence and importance of proteoglycans in the tissue architecture and extracellular matrix organization.