TY - JOUR T1 - The Effects of <em>PON1</em> Gene Q192R Variant on the Development of Uterine Leiomyoma in Turkish Patients JF - In Vivo JO - In Vivo SP - 243 LP - 246 VL - 29 IS - 2 AU - RUKSET ATTAR AU - HANDE ATASOY AU - GÜLDAL İNAL-GÜLTEKIN AU - ÖZLEM TİMİRCİ-KAHRAMAN AU - SEDA GÜLEÇ-YILMAZ AU - ALTAY BURAK DALAN AU - GAZİ YILDIRIM AU - ARZU ERGEN AU - TURGAY İSBİR Y1 - 2015/03/01 UR - http://iv.iiarjournals.org/content/29/2/243.abstract N2 - Aim: This study aimed to analyze the relation between uterine leiomyoma (ULM) patients and p.Q192R polymorphism. Materials and Methods: ULM patients (n=76) and healthy women (n=103) were recruited from the Yeditepe University, Department of Gynecology and Obstetrics. The genotype and allele distribution of p.Q192R was analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. Genotype and allele frequencies between study groups were calculated by the chi-square (χ2) and Fischer's exact test. Results: The frequency of the B allele was lower in patients (p&lt;0.001) and the AB genotype showed a decreased risk for ULM development (p&lt;0.001). The variation was unrelated to ULM size and number. There was no significant difference between p.Q192R genotype frequencies and fibroid size and number. Conclusion: The heterogeneous AB genotype of PON1 p.Q192R variation could be recognized as a low-risk parameter for the development of ULM in Turkish women. ER -