%0 Journal Article %A ADAM VARGA %A BARBARA SANDOR %A KAROLY KALMAR NAGY %A DORA PRAKSCH %A KATALIN GOMBOS %A ANDRAS TOTH %A KALMAN TOTH %A PETER SZAKALY %T Clopidogrel Resistance After Renal Transplantation %D 2015 %J In Vivo %P 301-303 %V 29 %N 2 %X Background: Leading causes of mortality and morbidity after kidney transplantation are cardiovascular diseases. One of the fundamentals of their prevention is the inhibition of platelet aggregation. Resistance to anti-platelet agents is a well-established phenomenon; however, its causes are yet to be clarified. Patients and Methods: Forty post-transplant patients, who received 75 mg clopidogrel q.d. as a prophylactic measure, were examined using optical aggregometry. Subsequently, logistic regression analysis was performed with 24 variables in order to expose possible causes of resistance. Results: Sixty percent of patients (24) were resistant to clopidogrel therapy; effective thrombocyte inhibition could only be shown in 40% of them (16). Significant correspondence between resistance and variables could not be found. Conclusion: Clopidogrel resistance is expected to occur on a large scale in patients who underwent kidney transplant surgery. Thus, a key component of preventive therapy, which stresses the importance of discovering the cause of resistance so as to decrease mortality rates, is missing. %U https://iv.iiarjournals.org/content/invivo/29/2/301.full.pdf