RT Journal Article SR Electronic T1 MicroRNAs in Assisted Reproduction and their Potential Role in IVF Failure JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 169 OP 175 VO 29 IS 2 A1 CHARALAMPOS SIRISTATIDIS A1 PARASKEVI VOGIATZI A1 NIKOS BRACHNIS A1 ASPASIA LIASSIDOU A1 ZOE ILIODROMITI A1 STEFANO BETTOCCHI A1 CHARALAMPOS CHRELIAS YR 2015 UL http://iv.iiarjournals.org/content/29/2/169.abstract AB MicroRNAs (miRNAs) have recently emerged as important regulators of gene expression stability. In the endometrium, miRNAs are involved in the dynamic changes associated with the menstrual cycle, implicated in implantation and in reproductive disorders. We performed a review in an attempt to assess the potential biological pathways linking altered miRNAs profiles with in vitro fertilisation (IVF) failure. Crucially, as miRNAs appear to have a significant role in the course of reproduction, they are excellent research candidates with the potential to enable a better understanding over the underlying molecular activities that prevent implantation and further progression of the embryo. Further steps include in-depth pathway mapping of the implantation process and the characterization of the respective miRNAs and associated links. The efficiency of any intervention should determine whether miRNA profiling could possibly be adopted in routine practice to substantially improve the diagnostic accuracy and, in parallel, the directed treatment of the next-generation IVF.