<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">HANKEN, HENNING</style></author><author><style face="normal" font="default" size="100%">ALPERS, JANNA</style></author><author><style face="normal" font="default" size="100%">BÖBEL, MELANIE</style></author><author><style face="normal" font="default" size="100%">WÖLTJE, MICHAEL</style></author><author><style face="normal" font="default" size="100%">HARTJEN, PHILIP</style></author><author><style face="normal" font="default" size="100%">FRIEDRICH, REINHARD E.</style></author><author><style face="normal" font="default" size="100%">JUNG, OLE</style></author><author><style face="normal" font="default" size="100%">RENDENBACH, CARSTEN</style></author><author><style face="normal" font="default" size="100%">GRÖBE, ALEXANDER</style></author><author><style face="normal" font="default" size="100%">HEILAND, MAX</style></author><author><style face="normal" font="default" size="100%">AL-DAM, AHMAD</style></author><author><style face="normal" font="default" size="100%">EICHHORN, WOLFGANG</style></author><author><style face="normal" font="default" size="100%">SMEETS, RALF</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Bone Substitutes Enhance Osteogenic Differentiation of Mesenchymal Stem Cells in Three-dimensional Scaffolds</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014-09-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">733-739</style></pages><volume><style face="normal" font="default" size="100%">28</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">Aim: The present study aimed to find bone substitutes to enhance osteogenic differentiation of mesenchymal stem cells in three-dimensional scaffolds in the absence of dexamethasone. Materials and Methods: Seven commercial bone substitutes were added to a three-dimensional fibrin-matrix containing rat mesenchymal stem cells in a biocompatible poly-L-lactic-acid mesh. Cell viability, cytotoxicity and alkaline phosphatase activity were followed for three weeks. Expression of bone markers was examined by qualitative evaluation of corresponding transcripts. Results: Six out of the seven bone derivatives exhibited an osteogenic-enhancing effect. Conclusion: The osteogenic-enhancing effect of the evaluated bone substitutes suggests their potential clinical application for preparation of autologous bone replacement material in three-dimensional carriers.</style></abstract></record></records></xml>