PT - JOURNAL ARTICLE AU - BETUL CEVIK AU - SERBULENT YIGIT AU - NEVIN KARAKUS AU - DURDANE AKSOY AU - OMER ATES AU - SEMÄ°HA KURT TI - Lack of Association Between <em>MIF</em> Gene -173G&gt;C Polymorphism with Multiple Sclerosis DP - 2015 Jan 01 TA - In Vivo PG - 71--76 VI - 29 IP - 1 4099 - http://iv.iiarjournals.org/content/29/1/71.short 4100 - http://iv.iiarjournals.org/content/29/1/71.full SO - In Vivo2015 Jan 01; 29 AB - Aim: The aim of the present study was to investigate a possible association between the MIF -173G&gt;C polymorphism and MS in Turkish patients. Materials and Methods: The study included 153 MS-patients and 210 controls. Genomic DNA was isolated and genotyped using PCR-RFLP assay for the MIF -173G&gt;C promoter polymorphism (rs755622). Results: There was no statistically significant difference in allele and genotype frequencies between MS-patients and controls (p=0.227 and p=0.157, respectively). Accordingly, no association was observed when the patients were compared against controls in terms of GG versus GC+CC genotypes and GG+GC versus CC genotypes (p=0.324 and p=0.179, respectively). Also, there was no statistically significant association between MIF-173G&gt;C polymorphism and clinical and demographic characteristics of MS-patients. Conlusion: The results of the present study suggest no relation between MS susceptibility and MIF gene - 173G&gt;C polymorphism in the examined Turkish population.