RT Journal Article SR Electronic T1 Genotoxic Effects of Prenatal Exposure to Levetiracetam During Pregnancy on Rat Offsprings JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 77 OP 81 VO 29 IS 1 A1 SENGUL TURAL A1 AKIN TEKCAN A1 MEHMET ELBISTAN A1 NEVIN KARAKUŞ A1 HAMIT OZYUREK A1 NURTEN KARA YR 2015 UL http://iv.iiarjournals.org/content/29/1/77.abstract AB Levetiracetam is a new-generation antiepileptic drug initially approved as an adjunctive treatment for patients with refractory partial seizures and is now also used as a monotherapy. The aim of this study was to evaluate the genotoxic effects of levetiracetam exposure during pregnancy on rat offsprings. In this study, we used the newborn pups of rats exposed to levetiracetam during pregnancy. Thirty Sprague-Dawley rats were divided into three groups. The mother rats of groups 1 and 2 were treated with different doses of levetiracetam (25 mg/kg/d and 50 mg/kg/d) from gestational days 1 to 18 during pregnancy. Group 3 (control group) was not treated with any drug. In vivo sister chromatid exchange (SCE) induction and in vivo micronucleus formation were assessed. Bone marrow from rat pups were used for investigation. As a result of this study, levetiracetam exposure did not alter SCE frequencies or the mean of number of micronuclei in the prenatal period (p>0.05). Levetiracetam did not cause miscarriage during pregnancy in mother rats. The present study highlighted fetal safety after prenatal exposure to levetiracetam.