RT Journal Article SR Electronic T1 Effects of Interactions Between Progesterone and Prostaglandin on Uterine Contractility in a Perfused Swine Uterus Model JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 467 OP 475 VO 28 IS 4 A1 JULIAN KÜNZEL A1 KLAUDIJA GEISLER A1 THEODOROS MALTARIS A1 ANDREAS MÜLLER A1 INGE HOFFMANN A1 HEIKE SCHNEIDER A1 MATTHIAS W. BECKMANN A1 RALF DITTRICH A1 PATRICIA G. OPPELT YR 2014 UL http://iv.iiarjournals.org/content/28/4/467.abstract AB Background/Aim: Uterine quiescence at the time of embryo transfer is a prerequisite for successful in vitro fertilization (IVF). This study assessed whether prostaglandin-induced contractions in the perfused swine uterus can be reduced by progesterone. Materials and Methods: Fifty-eight non-pregnant swine uteri were perfused using an established extracorporeal perfusion model. Intrauterine pressure changes during perfusion with prostaglandin (PG) administration (PGE1, PGE2, PGF2α) and progesterone (1 pg/ml, 10 pg/ml, 25 pg/ml, 50 pg/ml) were assessed using an intrauterine double-chip microcatheter. Results: The contraction-stimulating effect of PGs was clearly reduced by progesterone. Only PGE1 still triggered relevant contractions during continuous perfusion with progesterone solution, up to a concentration of 10 pg/ml. With PGE2 and PGF2α, a clear reduction of uterine contractility was observed even at at a progesterone concentration of 1 pg/ml. Conclusion: The extracorporal perfusion model of swine uteri shows that PG-induced contractions can be reduced in a dose-dependent manner by progesterone.