%0 Journal Article %A JULIAN KÜNZEL %A KLAUDIJA GEISLER %A THEODOROS MALTARIS %A ANDREAS MÜLLER %A INGE HOFFMANN %A HEIKE SCHNEIDER %A MATTHIAS W. BECKMANN %A RALF DITTRICH %A PATRICIA G. OPPELT %T Effects of Interactions Between Progesterone and Prostaglandin on Uterine Contractility in a Perfused Swine Uterus Model %D 2014 %J In Vivo %P 467-475 %V 28 %N 4 %X Background/Aim: Uterine quiescence at the time of embryo transfer is a prerequisite for successful in vitro fertilization (IVF). This study assessed whether prostaglandin-induced contractions in the perfused swine uterus can be reduced by progesterone. Materials and Methods: Fifty-eight non-pregnant swine uteri were perfused using an established extracorporeal perfusion model. Intrauterine pressure changes during perfusion with prostaglandin (PG) administration (PGE1, PGE2, PGF2α) and progesterone (1 pg/ml, 10 pg/ml, 25 pg/ml, 50 pg/ml) were assessed using an intrauterine double-chip microcatheter. Results: The contraction-stimulating effect of PGs was clearly reduced by progesterone. Only PGE1 still triggered relevant contractions during continuous perfusion with progesterone solution, up to a concentration of 10 pg/ml. With PGE2 and PGF2α, a clear reduction of uterine contractility was observed even at at a progesterone concentration of 1 pg/ml. Conclusion: The extracorporal perfusion model of swine uteri shows that PG-induced contractions can be reduced in a dose-dependent manner by progesterone. %U https://iv.iiarjournals.org/content/invivo/28/4/467.full.pdf