%0 Journal Article %A LIEN-CHUAN YANG %A YU-PING HSIAO %A CHUN-TE LU %A CHUN-HUANG HUANG %A WAN-RU CHAO %A YU-TING LIN %A HSUAN-AN SU %A SHIH-LIANG CHANG %A JING-GUNG CHUNG %T Xeroderma Pigmentosum Complementation Group C Protein (XPC) Expression in Basal Cell Carcinoma %D 2015 %J In Vivo %P 35-38 %V 29 %N 1 %X Background: The Xeroderma pigmentosum complementation group C protein (XPC) is a general sensor of damaged DNA. Individuals carrying a mutation in XPC genes exhibit marked photosensitivity and increased occurrence of skin cancers. Little is known about the distribution of XPC protein in basal cell carcinoma (BCC). Aim: To determine whether the XPC protein is associated with basal cell carcinoma. Materials and Methods: In the present study, we investigated the protein expression of XPC by immunohistochemistry in 86 cases of BCC and paired-adjacent normal epidermis. Results: The intensity of nuclear XPC expression was significantly higher in BCC compared to adjacent normal epidermis (p<0.001). Attenuated XPC expression was associated with high-risk BCC (p=0.045) but was not significantly associated with age, gender and body area. Conclusion: Our results indicate that XPC is associated with BCC and further studies are warranted to determine if the XPC-BCC interaction is specific to just one cancer cell type and to investigate potential mechanisms. %U https://iv.iiarjournals.org/content/invivo/29/1/35.full.pdf