PT  - JOURNAL ARTICLE
AU  - ADAM VARGA
AU  - BARBARA SANDOR
AU  - KAROLY KALMAR NAGY
AU  - MARIA VIOLA
AU  - ANDRAS TOTH
AU  - KATALIN GOMBOS
AU  - KALMAN TOTH
AU  - PETER SZAKALY
TI  - Acetylsalicylic Acid Resistance After Renal Transplantation
DP  - 2015 Jan 01
TA  - In Vivo
PG  - 141--144
VI  - 29
IP  - 1
4099  - http://iv.iiarjournals.org/content/29/1/141.short
4100  - http://iv.iiarjournals.org/content/29/1/141.full
SO  - In Vivo2015 Jan 01; 29
AB  - Background: Cardiovascular diseases are a leading cause of mortality after kidney transplantation. According to guidelines, acetylsalicylic acid (ASA) must be given as preventive antiplatelet therapy, but resistance to this drug is also well-known. Patients and Methods: A total of 214 renal transplant patients were included in our study and took 100 mg of ASA q.d. Aggregometry was performed to determine resistance. Twenty-four variables were examined using logistic regression analysis as possible causes of resistance. Results: ASA resistance was observed in 40.18% of the patients. Resistance reduced concomitant statin therapy and significantly increased simultaneous cyclosporine therapy. Conclusion: Our study assessed the post-transplant ASA resistance in a large population. Clarification of this matter is crutial, since one of the major preventive pharmacological therapies of cardiovascular mortality is not effective in a significant number of patients.