TY - JOUR T1 - Exposure to Varicella Zoster Virus Is Higher in Children with Autism Spectrum Disorder than in Healthy Controls. Results from a Case-control Study JF - In Vivo JO - In Vivo SP - 627 LP - 631 VL - 28 IS - 4 AU - IVAN GENTILE AU - EMANUELA ZAPPULO AU - RAFFAELE BONAVOLTA AU - ROBERTA MARESCA AU - MARIA PIA RICCIO AU - ANTONIO RICCARDO BUONOMO AU - GIUSEPPE PORTELLA AU - ALESSANDRO SETTIMI AU - ANTONIO PASCOTTO AU - GUGLIELMO BORGIA AU - CARMELA BRAVACCIO Y1 - 2014/07/01 UR - http://iv.iiarjournals.org/content/28/4/627.abstract N2 - Background/Aim: Autism spectrum disorder (ASD) is a group of central nervous system disorders lacking a definite etiology. The aim of the present study was to compare the exposure rate and titer of antibodies to Varicella Zoster Virus (VZV) in children with ASD and in healthy controls. Patients and Methods: We enrolled 54 children with ASD and 46 control individuals. Results: The exposure rate and titer of anti-VZV antibodies were significantly higher in children with ASD compared to controls (59% vs. 39% and 694 mIU/ml vs. 94 mIU/ml, respectively). Conclusion: In the present case-control study, exposure to VZV was found to be independently associated with ASD. ER -