PT  - JOURNAL ARTICLE
AU  - PETER P. SORDILLO
AU  - LAWRENCE HELSON
TI  - Curcumin Suppression of Cytokine Release and Cytokine Storm. A Potential Therapy for Patients with Ebola and Other Severe Viral Infections
DP  - 2015 Jan 01
TA  - In Vivo
PG  - 1--4
VI  - 29
IP  - 1
4099  - http://iv.iiarjournals.org/content/29/1/1.short
4100  - http://iv.iiarjournals.org/content/29/1/1.full
SO  - In Vivo2015 Jan 01; 29
AB  - Background: The terminal stage of Ebola and other viral diseases is often the onset of a cytokine storm, the massive overproduction of cytokines by the body's immune system. Materials and Methods: The actions of curcumin in suppressing cytokine release and cytokine storm are discussed. Results: Curcumin blocks cytokine release, most importantly the key pro-inflammatory cytokines, interleukin-1, interleukin-6 and tumor necrosis factor-α. The suppression of cytokine release by curcumin correlates with clinical improvement in experimental models of disease conditions where a cytokine storm plays a significant role in mortality. Conclusion: The use of curcumin should be investigated in patients with Ebola and cytokine storm. Intravenous formulations may allow achievement of therapeutic blood levels of curcumin