TY - JOUR T1 - HSV1 and 2 Detection in the CSF of Multiple Sclerosis Patients by Real-time PCR JF - In Vivo JO - In Vivo SP - 1201 LP - 1205 VL - 28 IS - 6 AU - CHRISTOS KOROS AU - ANASTASIOS IOANNIDIS AU - TEREZA ACQUAVIVA AU - MARGARITA ZOGA AU - CHRYSSOULA NIKOLAOU AU - STYLIANOS CHATZIPANAGIOTOU AU - ATHANASSIOS KOSSYVAKIS AU - MARIA ANAGNOSTOULI Y1 - 2014/11/01 UR - http://iv.iiarjournals.org/content/28/6/1201.abstract N2 - Aim: The pathogenic role of Herpes Simplex Virus (HSV) 1 and 2 in Multiple Sclerosis (MS) still remains obscure. The aim of our study was the assessment of HSV1 and 2 DNA prevalence in the cerebrospinal fluid (CSF) of MS patients compared to patients with other neurological disorders (OND). Materials and Methods: HSV1 and HSV2 DNA detection in the CSF of patients was performed by real time polymerase chain reaction (PCR). Results: The genome of HSV1 was present in the CSF of 4.7% of MS patients (4 out of 85), while HSV2 was not detected in any patient. In the sub-group of OND patients, HSV1 was detected in 7.9% of patients (3 out of 38) and HSV2 was detected in 5.3% of patients (2 out of 38). Conclusion: Our data are in accordance with a limited number of previous reports, supporting a prevalence of HSV1 genome in less than 5% of MS patients. ER -