RT Journal Article
SR Electronic
T1 HSV1 and 2 Detection in the CSF of Multiple Sclerosis Patients by Real-time PCR
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1201
OP 1205
VO 28
IS 6
A1 CHRISTOS KOROS
A1 ANASTASIOS IOANNIDIS
A1 TEREZA ACQUAVIVA
A1 MARGARITA ZOGA
A1 CHRYSSOULA NIKOLAOU
A1 STYLIANOS CHATZIPANAGIOTOU
A1 ATHANASSIOS KOSSYVAKIS
A1 MARIA ANAGNOSTOULI
YR 2014
UL http://iv.iiarjournals.org/content/28/6/1201.abstract
AB Aim: The pathogenic role of Herpes Simplex Virus (HSV) 1 and 2 in Multiple Sclerosis (MS) still remains obscure. The aim of our study was the assessment of HSV1 and 2 DNA prevalence in the cerebrospinal fluid (CSF) of MS patients compared to patients with other neurological disorders (OND). Materials and Methods: HSV1 and HSV2 DNA detection in the CSF of patients was performed by real time polymerase chain reaction (PCR). Results: The genome of HSV1 was present in the CSF of 4.7% of MS patients (4 out of 85), while HSV2 was not detected in any patient. In the sub-group of OND patients, HSV1 was detected in 7.9% of patients (3 out of 38) and HSV2 was detected in 5.3% of patients (2 out of 38). Conclusion: Our data are in accordance with a limited number of previous reports, supporting a prevalence of HSV1 genome in less than 5% of MS patients.