TY - JOUR T1 - Melatonin Does Not Affect Oxidative/Inflammatory Biomarkers in a Closed-Chest Porcine Model of Acute Myocardial Infarction JF - In Vivo JO - In Vivo SP - 483 LP - 488 VL - 28 IS - 4 AU - NATALIE L. HALLADIN AU - SARAH EKELØF AU - SVEND EGGERT JENSEN AU - JENS AARØE AU - BENEDICT KJÆRGAARD AU - PETER M. H. HEEGAARD AU - JENS LYKKESFELDT AU - JACOB ROSENBERG AU - ISMAIL GÖGENUR Y1 - 2014/07/01 UR - http://iv.iiarjournals.org/content/28/4/483.abstract N2 - Aim: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. Materials and Methods: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion. Results: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups. Conclusion: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo. ER -