PT  - JOURNAL ARTICLE
AU  - IVAN GENTILE
AU  - EMANUELA ZAPPULO
AU  - RAFFAELE BONAVOLTA
AU  - ROBERTA MARESCA
AU  - MARIA PIA RICCIO
AU  - ANTONIO RICCARDO BUONOMO
AU  - GIUSEPPE PORTELLA
AU  - LUCA VALLEFUOCO
AU  - ALESSANDRO SETTIMI
AU  - ANTONIO PASCOTTO
AU  - GUGLIELMO BORGIA
AU  - CARMELA BRAVACCIO
TI  - Prevalence of Herpes Simplex Virus 1 and 2 Antibodies in Patients with Autism Spectrum Disorders
DP  - 2014 Jul 01
TA  - In Vivo
PG  - 667--671
VI  - 28
IP  - 4
4099  - http://iv.iiarjournals.org/content/28/4/667.short
4100  - http://iv.iiarjournals.org/content/28/4/667.full
SO  - In Vivo2014 Jul 01; 28
AB  - Background/Aim: The etiology of autism spectrum disorder (ASD) is unknown, even though it is hypothesized that a viral infection could trigger this disorder. The aim of this study was to evaluate the seropositivity rate and antibody level of Herpes Simplex Virus 1 (HSV1) and Herpes Simplex Virus 2 (HSV2) in children with ASD compared to same-aged healthy controls. Patients and Methods: We compared seropositivity rate and levels of antibodies to HSV1/2 in 54 children with ASD (19 with autistic disorder and 35 with non-autistic ASD) and in 46 controls. Results: Seropositivity rate and levels of anti-HSV1/2 were not dissimilar between cases and controls. Exposure to HSV2 was minimal. Conclusion: Rate of contact with HSV1 and HSV2 assessed by the mean of detection of specific antibodies was similar between children with ASD and healthy controls.