RT Journal Article
SR Electronic
T1 Alpha-phellandrene Promotes Immune Responses in Normal Mice Through Enhancing Macrophage Phagocytosis and Natural Killer Cell Activities
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 809
OP 814
VO 27
IS 6
A1 JEN-JYH LIN
A1 JU-HWA LIN
A1 SHU-CHUN HSU
A1 SHU-WEN WENG
A1 YI-PING HUANG
A1 NOU-YING TANG
A1 JAUNG-GENG LIN
A1 JING-GUNG CHUNG
YR 2013
UL http://iv.iiarjournals.org/content/27/6/809.abstract
AB α-Phellandrene, a natural compound from natural plants, has been used in the food and perfume industry. We investigated the effects of α-phellandrene on the immune responses on normal murine cells in vivo. Normal BALB/c mice were treated orally with or without α-phellandrene at 0, 1, 5 and 25 mg/kg and olive oil as a positive control for two weeks. Results indicated that α-phellandrene did not change the weight of animals when compared to olive oil (vehicle for α-phellandrene)-treated groups. After flow cytometric assay of blood samples it was shown that α-phellandrene increased the percentage of CD3 (T-cell marker), CD11b (monocytes) and MAC3 (macrophages), but reduced the percentage of CD19 (B-cell marker) cell surface markers in α-phellandrene-treated groups, compared to untreated groups. α-Phellandrene promoted the phagocytosis of macrophages from blood samples at 5 and 25 mg/kg treatment and promoted natural killer cell activity from splenocytes at 25 mg/kg. Furthermore, α-phellandrene increased B-cell proliferation at 25 mg/kg with or without stimulation but promoted cell proliferation only at 25 mg/kg treatment with stimulation. Based on these observations, 25 mg/kg with α-phellandrene seems to have promoted immune responses in this murine model.