RT Journal Article
SR Electronic
T1 Role of Cytokines as a Double-edged Sword in Sepsis
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 669
OP 684
VO 27
IS 6
A1 HINA CHAUDHRY
A1 JUHUA ZHOU
A1 YIN ZHONG
A1 MIR MUSTAFA ALI
A1 FRANKLIN MCGUIRE
A1 PRAKASH S. NAGARKATTI
A1 MITZI NAGARKATTI
YR 2013
UL http://iv.iiarjournals.org/content/27/6/669.abstract
AB Background: Sepsis is a deadly immunological disorder and its pathophysiology is still poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory cytokines can be used as diagnostic and therapeutic targets for sepsis. Materials and Methods: Recent publications in the MEDLINE database were searched for articles regarding the clinical significance of inflammatory cytokines in sepsis. Results: In response to pathogen infection, pro-inflammatory cytokines [interleukin-6 (IL-6), IL-8, IL-18 and tumor necrosis factor-α (TNF-α)] and anti-inflammatory cytokine (IL-10) increased in patients with sepsis. Importantly, a decrease in IL-6 was associated with a better prognosis and overproduction of IL-10 was found to be the main predictor of severity and fatal outcome. Conclusion: Both pro-inflammatory and anti-inflammatory cytokines constitute a double-edged sword in sepsis; on one hand they are critical to eliminate the infection while on the other, excessive production can cause tissue and organ damage. Increase in cytokines such as IL-6, Il-8, IL-10, IL-18 and TNF-α may have implications in diagnosis and treatment of sepsis.