TY - JOUR T1 - Effects of Nebivolol on Liver Fibrosis Induced by Bile Duct Ligation in Wistar Rats JF - In Vivo JO - In Vivo SP - 635 LP - 640 VL - 27 IS - 5 AU - CATARINA TEIXEIRA AU - ELISABETE FRANCO AU - PAULA ALEXANDRA OLIVEIRA AU - BRUNO COLAÇO AU - ADELINA GAMA AU - JOÃO CARROLA AU - CARLOS ANDRÉ PIRES AU - AURA COLAÇO AU - MARIA JOÃO PIRES Y1 - 2013/09/01 UR - http://iv.iiarjournals.org/content/27/5/635.abstract N2 - Aim: To study the effect of nebivolol on liver fibrosis induced by common bile duct ligation (BDL) in rats. Materials and Methods: After BDL, Wistar rats were divided into three groups (n=24): SO, sham-operated animals; BDL, BDL rats without treatment; BDL+N, BDL rats treated with nebivolol for five weeks. Alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, total bilirubin and albumin levels were assessed. Liver samples collected were stained with hematoxylin-eosin, Masson's trichrom and reticulin. Results: Mortality reached 37.5% in the BDL group, whereas no deaths were observed in the SO and BDL+N groups. The BDL group showed hepatic damage as evidenced by elevation in serum biochemical parameters and fibrosis scores. These pathophysiological changes were attenuated in the BDL+N group. However, there was no significant difference between these two groups. Conclusion: Nebivolol improved the survival rate of animals with BDL, but was unable to significantly improve liver function or reduce liver fibrosis. ER -