RT Journal Article
SR Electronic
T1 Effects of Nebivolol on Liver Fibrosis Induced by Bile Duct Ligation in Wistar Rats
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 635
OP 640
VO 27
IS 5
A1 CATARINA TEIXEIRA
A1 ELISABETE FRANCO
A1 PAULA ALEXANDRA OLIVEIRA
A1 BRUNO COLAÇO
A1 ADELINA GAMA
A1 JOÃO CARROLA
A1 CARLOS ANDRÉ PIRES
A1 AURA COLAÇO
A1 MARIA JOÃO PIRES
YR 2013
UL http://iv.iiarjournals.org/content/27/5/635.abstract
AB Aim: To study the effect of nebivolol on liver fibrosis induced by common bile duct ligation (BDL) in rats. Materials and Methods: After BDL, Wistar rats were divided into three groups (n=24): SO, sham-operated animals; BDL, BDL rats without treatment; BDL+N, BDL rats treated with nebivolol for five weeks. Alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, total bilirubin and albumin levels were assessed. Liver samples collected were stained with hematoxylin-eosin, Masson's trichrom and reticulin. Results: Mortality reached 37.5% in the BDL group, whereas no deaths were observed in the SO and BDL+N groups. The BDL group showed hepatic damage as evidenced by elevation in serum biochemical parameters and fibrosis scores. These pathophysiological changes were attenuated in the BDL+N group. However, there was no significant difference between these two groups. Conclusion: Nebivolol improved the survival rate of animals with BDL, but was unable to significantly improve liver function or reduce liver fibrosis.