PT  - JOURNAL ARTICLE
AU  - JOZEF ZUSTIN
AU  - HANNA A. SCHEUER
AU  - RAINALD KNECHT
AU  - REINHARD E. FRIEDRICH
TI  - Enhanced Podoplanin Expression in Chronic Maxillary Sinusitis
DP  - 2013 Jul 01
TA  - In Vivo
PG  - 551--554
VI  - 27
IP  - 4
4099  - http://iv.iiarjournals.org/content/27/4/551.short
4100  - http://iv.iiarjournals.org/content/27/4/551.full
SO  - In Vivo2013 Jul 01; 27
AB  - Podoplanin expression has been reported in oral squamous epithelium, myoepithelia of the salivary glands, and odontogenic lesions, and has been linked with inflammatory and neoplastic conditions. We hypothesized that inflamed respiratory mucosa of the maxillary sinus also express podoplanin, especially in cases with odontogenic sinusitis. We retrospectively investigated podoplanin expression in biopsies from maxillary sinus with inflammatory changes. Cases with chronic rhinosinusitis with polyp formation (n=5), chronic rhinosinusitis without polyps (n=5), chronic rhinosinusitis with eosinophilia (n=5), and odontogenic chronic rhinosinusitis (n=5) were investigated immunohistochemically using an established antibody for podoplanin (D2-40). Respiratory epithelium in chronic maxillary sinusitis with polyp formation did not exhibit enhanced podoplanin expression. However, D2-40 positivity was detected in the basal cells in all cases with chronic sinusitis associated with inflammatory infiltrations as well as in the parabasal epithelial layer in chronic sinusitis without polyp formation. We observed podoplanin expression in non-neoplastic maxillary sinus epithelium exhibiting inflammatory changes. We suggest that podoplanin is involved in the pathogenesis of chronic rhinosinusitis, particularly in the intraepithelial migration of inflammatory infiltrates.