RT Journal Article
SR Electronic
T1 Concomitant Interferon-alpha and Chemotherapy in Hepatitis C and Colorectal Cancer: A Case Report
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 527
OP 529
VO 27
IS 4
A1 IVAN GENTILE
A1 ALFONSO DE STEFANO
A1 GIUSY DI FLUMERI
A1 ANTONIO RICCARDO BUONOMO
A1 CHIARA CARLOMAGNO
A1 FILOMENA MORISCO
A1 SABINO DE PLACIDO
A1 GUGLIELMO BORGIA
YR 2013
UL http://iv.iiarjournals.org/content/27/4/527.abstract
AB Hepatitis C virus (HCV) infection is one of the main causes of liver disease worldwide. Patients undergoing surgery are at risk of acquiring acute HCV infection and those undergoing surgical eradication of a neoplasia may be indicated for adjuvant treatment. Therefore, unlike chronic infection, these patients may simultaneously need antiviral therapy with interferon for acute hepatitis C and cytotoxic chemotherapy. To date, no data are available regarding the efficacy and tolerability of concomitant interferon treatment and antineoplastic chemotherapy in the setting of acute hepatitis C treatment. Here, we report the case of a 60-year-old man who developed acute hepatitis C after left hemicolectomy for an adenocarcinoma. He received concomitant antiviral treatment with interferon-α and adjuvant chemotherapy with capecitabine and oxaliplatin. Both treatments were well-tolerated and the patient completed the scheduled therapies. HCV infection was eradicated and the patient is free of neoplastic disease two years and 6 months after surgery.