TY - JOUR T1 - Coagulation Activity and White Thrombus Formation in the Microminipig JF - In Vivo JO - In Vivo SP - 357 LP - 361 VL - 27 IS - 3 AU - NAOKI MIURA AU - HIROAKI KAWAGUCHI AU - TOMOKA NAGASATO AU - TOMONOBU YAMADA AU - TAKASHI ITO AU - HIROYUKI IZUMI AU - HISAYO SHAMESHIMA AU - NORIAKI MIYOSHI AU - AKIHIDE TANIMOTO AU - IKURO MARUYAMA Y1 - 2013/05/01 UR - http://iv.iiarjournals.org/content/27/3/357.abstract N2 - Swine are becoming increasingly attractive as animal models for clinical research and the recently developed Microminipig (MMPig) has emerged as a possible experimental animal model. In this study, we demonstrated age-dependent changes in hematological parameters and coagulation activity in healthy MMPigs (58 male and 67 females, aged 0-34 months), and investigated white thrombus formation (WTF) using an in vitro microchip flow-chamber system (four males and four females, aged 22-23 months). There was no clear sex or age-dependent differences in any hematological parameters. While activated partial thromboplastin time (APTT) was shorter than prothrombin time (PT), with APTT:PT of 0.88:1, microchip flow-chamber system analysis showed that WTF time was shorter than that in humans, suggesting a possible thrombotic tendency in the MMPig. These results could be useful to life science researchers in the use of the MMPig as an experimental model animal for thrombus formation. ER -