PT  - JOURNAL ARTICLE
AU  - NAOKI MIURA
AU  - HIROAKI KAWAGUCHI
AU  - TOMOKA NAGASATO
AU  - TOMONOBU YAMADA
AU  - TAKASHI ITO
AU  - HIROYUKI IZUMI
AU  - HISAYO SHAMESHIMA
AU  - NORIAKI MIYOSHI
AU  - AKIHIDE TANIMOTO
AU  - IKURO MARUYAMA
TI  - Coagulation Activity and White Thrombus Formation in the Microminipig
DP  - 2013 May 01
TA  - In Vivo
PG  - 357--361
VI  - 27
IP  - 3
4099  - http://iv.iiarjournals.org/content/27/3/357.short
4100  - http://iv.iiarjournals.org/content/27/3/357.full
SO  - In Vivo2013 May 01; 27
AB  - Swine are becoming increasingly attractive as animal models for clinical research and the recently developed Microminipig (MMPig) has emerged as a possible experimental animal model. In this study, we demonstrated age-dependent changes in hematological parameters and coagulation activity in healthy MMPigs (58 male and 67 females, aged 0-34 months), and investigated white thrombus formation (WTF) using an in vitro microchip flow-chamber system (four males and four females, aged 22-23 months). There was no clear sex or age-dependent differences in any hematological parameters. While activated partial thromboplastin time (APTT) was shorter than prothrombin time (PT), with APTT:PT of 0.88:1, microchip flow-chamber system analysis showed that WTF time was shorter than that in humans, suggesting a possible thrombotic tendency in the MMPig. These results could be useful to life science researchers in the use of the MMPig as an experimental model animal for thrombus formation.