<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">PIRES, ISABEL</style></author><author><style face="normal" font="default" size="100%">RODRIGUES, PAULA</style></author><author><style face="normal" font="default" size="100%">ALVES, ANABELA</style></author><author><style face="normal" font="default" size="100%">QUEIROGA, FELISBINA LUISA</style></author><author><style face="normal" font="default" size="100%">SILVA, FILIPE</style></author><author><style face="normal" font="default" size="100%">LOPES, CARLOS</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunohistochemical and Immunoelectron Study of Major Histocompatibility Complex Class-II Antigen in Canine Cutaneous Histiocytoma: Its Relation to Tumor Regression</style></title><secondary-title><style face="normal" font="default" size="100%">In Vivo</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2013-03-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">257-262</style></pages><volume><style face="normal" font="default" size="100%">27</style></volume><issue><style face="normal" font="default" size="100%">2</style></issue><abstract><style  face="normal" font="default" size="100%">In order to investigate the immune mechanisms involved in regression of canine cutaneous histicytoma (CCH), major histocompatibility complex (MHC) class-II immuno-expression and the number of T- and B-lymphocytes and macrophages were analyzed in 93 cases of CCH. MHC class-II was also studied in 16 cases of CCH by immunoelectron microscopy. All tumors expressed MHC class-II, and two major staining patterns were identified: focal juxtanuclear cytoplasmic staining and rim-like staining along the cell periphery. The MHC class-II labelling pattern and T- and B-lymphocyte infiltrates were associated with tumor regression. In regressing lesions, MHC class-II molecules shift to the cell surface and an increase of both T- and B-lymphocytes were noted. The increasing expression of MHC class-II molecules on the cell surface could be a significant factor for the onset and progression of tumour regression.</style></abstract></record></records></xml>