RT Journal Article
SR Electronic
T1 Immunohistological Characterization of Thymic Dendritic Cells
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 985
OP 992
VO 26
IS 6
A1 ALEXANDRA PAPOUDOU-BAI
A1 MARIA BAI
A1 MICHALIS DOUKAS
A1 KALLIOPI STEFANAKI
A1 PANAGIOTA SPYRIDONOS
A1 GEORGE KARATZIAS
A1 ALEXANDRA BARBOUTI
A1 VASSILIKI GALANI
A1 PANAGIOTIS KANAVAROS
YR 2012
UL http://iv.iiarjournals.org/content/26/6/985.abstract
AB Background: Dendritic cells play key roles in thymic histophysiology and histopathology. Therefore, we analyzed the immunotopographical distribution of cells expressing markers of dendritic cells and macrophages in postnatal human thymus. Materials and Methods: The streptavidin-biotin peroxidise-labeled (LSAB) and the double-LSAB/alkaline phosphatase/anti-alkaline phosphatase (APAAP) immunohistochemical procedures were used. Results: S100 protein-, Cluster of designation 1a (CD1a)-, CD207-, CD11c- and CD123-positive cells, many of them exhibiting the morphology of dendritic cells, were detected in the cortex but mainly in the medulla. These markers, except CD123, were also detected in cells of juvenile and immature Hassall bodies. CD68- and CD163-positive cells were detected in the cortex and the medulla but not in Hassall bodies. Conclusion: The immunohistological detection of S100-, CD1a-, CD207- and CD11c-positive dendritic cells in juvenile and immature Hassall bodies may reflect an important role of these structures in the cooperation of epithelial and dendritic cells in the process of T-cell differentiation.