TY - JOUR T1 - Palliative Intralesional Interleukin-2 Treatment in Dogs with Urinary Bladder and Urethral Carcinomas JF - In Vivo JO - In Vivo SP - 931 LP - 935 VL - 26 IS - 6 AU - URSULA KONIETSCHKE AU - ERIK TESKE AU - KONRAD JURINA AU - CHRISTIAN STOCKHAUS Y1 - 2012/11/01 UR - http://iv.iiarjournals.org/content/26/6/931.abstract N2 - Aim: The investigation of the influence of intralesional interleukin-2 (IL-2) on the clinical course and tumor progression in dogs suffering from urinary bladder and urethral carcinomas. Materials and Methods: Medical records of 25 dogs diagnosed with advanced transitional cell carcinomas (TCC) were retrospectively reviewed. In 14 dogs, intralesional IL-2 treatment was performed by transabdominal ultrasound-guided injection. Seven dogs underwent cytoreductive surgery, followed by IL-2 injection into the tumor bed. All dogs received long-term non-steroidal anti-inflammatory drugs. Results: Adverse effects associated with IL-2 treatment were not observed. At re-examination, 17 dogs showed marked clinical improvement and regression of tumor size. Four dogs were in complete remission. Conclusion: Intralesional IL-2 application is a safe and minimally-invasive palliative treatment option in dogs suffering from advanced transitional cell carcinoma when surgical cure is impossible. Prognosis depends on tumor localization and feasibility of concomitant cytoreductive surgery. ER -