TY - JOUR T1 - Pilot Clinical Study of <em>Sasa senanensis</em> Rehder Leaf Extract Treatment on Lichenoid Dysplasia JF - In Vivo JO - In Vivo SP - 957 LP - 962 VL - 26 IS - 6 AU - TOMOHIKO MATSUTA AU - HIROSHI SAKAGAMI AU - SHOJI TANAKA AU - MAMORU MACHINO AU - MINEKO TOMOMURA AU - AKITO TOMOMURA AU - TOSHIKAZU YASUI AU - KAZUYOSHI ITOH AU - TOMOKO SUGIURA AU - MADOKA KITAJIMA AU - HIROSHI OIZUMI AU - TAKAAKI OIZUMI Y1 - 2012/11/01 UR - http://iv.iiarjournals.org/content/26/6/957.abstract N2 - Background: Previous studies have shown antiviral, antibacterial, and anti-inflammatory activity of alkaline extract of the leaves of Sasa senanensis Rehder (SE). Here, we investigated whether SE is effective on oral lichenoid dysplasia and osteoclastogenesis. Materials and Methods: A male patient with white lacy streaks in the oral mucosa was orally administered SE three times a day for 11 months. The area of white streaks was monitored by intraoral photography. Interleukin-6 and -8 in the saliva were determined by enzyme-linked immunosorbent assay. Osteoclastogenesis of mouse macrophage-like RAW264.7 cells, induced by receptor activator of nuclear factor-κB ligand (RANKL) was monitored by tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cell formation. Results: Long-term treatment with SE progressively reduced both the area of white steaks and the levels of salivary interleukin-6 and -8. SE significantly inhibited the macrophage differentiation towards osteoclasts. Conclusion: The present study suggests the therapeutic potential of SE towards oral diseases. ER -