PT  - JOURNAL ARTICLE
AU  - FIORAMONTI, PAOLO
AU  - FINO, PASQUALE
AU  - PARISI, PAOLA
AU  - SCUDERI, NICOLO
AU  - ONESTI, MARIA G.
TI  - A Case of Hydroxyurea-induced Leg Ulcer after Definitive Treatment Suspension in a Patient Affected by Thrombocythemia: Effectiveness of a New Collagenase
DP  - 2012 Nov 01
TA  - In Vivo
PG  - 1053--1056
VI  - 26
IP  - 6
4099  - http://iv.iiarjournals.org/content/26/6/1053.short
4100  - http://iv.iiarjournals.org/content/26/6/1053.full
SO  - In Vivo2012 Nov 01; 26
AB  - Hydroxyurea (HU) is an antitumor agent effective in the treatment of myeloproliferative disorders. It is usually well-tolerated and has low toxicity but its use is associated with several adverse cutaneous effects. Among them, leg ulcers have been noted in association with long-term administration. Poor response to traditional local and systemic therapy is a typical feature of HU-induced leg ulcers, and discontinuation of the drug is often required to achieve complete wound healing. We present a case of circumferential HU-induced leg ulcer in a patient affected by essential thrombocythemia, in which the lesion occured after the definitive suspension of the treatment. We propose a conservative management with a new collagenase (Bionect Start®) for skin lesions in this type of patient, for whom a surgical treatment could be more complicated, due to the underlying disease.