RT Journal Article
SR Electronic
T1 Variations in the Expression and Distribution Pattern of AQP5 in Acinar Cells of Patients with Sialadenosis
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 951
OP 955
VO 26
IS 6
A1 TEYMOORTASH, AFSHIN
A1 WIEGAND, SUSANNE
A1 BORKELOH, MARTIN
A1 BETTE, MICHAEL
A1 RAMASWAMY, ANNETTE
A1 STEINBACH-HUNDT, SILKE
A1 NEFF, ANDREAS
A1 WERNER, JOCHEN A.
A1 MANDIC, ROBERT
YR 2012
UL http://iv.iiarjournals.org/content/26/6/951.abstract
AB Previously, we pointed out on a possible role of aquaporin 5 (AQP5) in the development of sialadenosis. The goal of the present study was to further assess the association of AQP5 in the development of this salivary gland disease. The acinar diameter and mean surface area appeared elevated in sialadenosis tissues, which is a typical observation in this disease. AQP5 expression was evaluated by immunohistochemistry using tissue samples derived from salivary glands of patients with confirmed sialadenosis either as a primary diagnosis or as a secondary diagnosis within the framework of other salivary gland diseases. Normal salivary gland tissue served as a control. In sialadenosis tissues, the AQP5 signal at the apical plasma membrane of acinar cells frequently appeared stronger compared with that in normal salivary glands. In addition, the distribution of AQP5 at the apical region seemed to differ between normal and sialadenosis tissues, where AQP5 frequently was diffusely distributed near or at the apical plasma membrane of the acinar cells in contrast to normal controls where the AQP5 signal was strictly confined to the apical plasma membrane. These observations suggest that sialadenosis is associated with a different AQP5 expression and distribution pattern in salivary acinar cells.