RT Journal Article
SR Electronic
T1 Endothelial Lipase Gene Polymorphism (584 C/T) in Coronary Artery Patients Among a Turkish Population
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1105
OP 1109
DO 10.21873/invivo.11352
VO 32
IS 5
A1 SOLİM, LEVENT AKMAN
A1 GENCAN, İZGI AYÇIL
A1 ÇELİK, BEHIÇ
A1 ATAACAR, ALARA
A1 KOÇ, UMUT
A1 BÜYÜKÖREN, BEYZA
A1 GÜNGÖR, GIZEM
A1 İSBİR, SELIM
YR 2018
UL http://iv.iiarjournals.org/content/32/5/1105.abstract
AB Background/Aim: The endothelial lipase gene (LIPG) has a major role in regulating high density lipoprotein cholesterol (HDL-C), therefore this study investigated whether LIPG is associated with coronary artery disease (CAD) in a Turkish population. Materials and Methods: The LIPG (584 C/T) mutation was analyzed in 74 CAD patients and 73 controls. Results: There was a significant difference between the two groups regarding the mutant T allele frequencies (χ2=0.456, p=0.020; 26.7% and 41.8% in patient and control groups, respectively) for 584 C/T. Even though the TT genotype was not significantly different, it had p=0.054 which supported our results. Conclusion: The endothelial lipase gene (584 C/T) T allele might be protective in association with coronary artery disease. Therefore, LIPG gene is related to risk for CAD in the Turkish population probably through altering HDL-C metabolism.