PT  - JOURNAL ARTICLE
AU  - SOLİM, LEVENT AKMAN
AU  - GENCAN, İZGI AYÇIL
AU  - ÇELİK, BEHIÇ
AU  - ATAACAR, ALARA
AU  - KOÇ, UMUT
AU  - BÜYÜKÖREN, BEYZA
AU  - GÜNGÖR, GIZEM
AU  - İSBİR, SELIM
TI  - Endothelial Lipase Gene Polymorphism (584 C/T) in Coronary Artery Patients Among a Turkish Population
AID  - 10.21873/invivo.11352
DP  - 2018 Sep 01
TA  - In Vivo
PG  - 1105--1109
VI  - 32
IP  - 5
4099  - http://iv.iiarjournals.org/content/32/5/1105.short
4100  - http://iv.iiarjournals.org/content/32/5/1105.full
SO  - In Vivo2018 Sep 01; 32
AB  - Background/Aim: The endothelial lipase gene (LIPG) has a major role in regulating high density lipoprotein cholesterol (HDL-C), therefore this study investigated whether LIPG is associated with coronary artery disease (CAD) in a Turkish population. Materials and Methods: The LIPG (584 C/T) mutation was analyzed in 74 CAD patients and 73 controls. Results: There was a significant difference between the two groups regarding the mutant T allele frequencies (χ2=0.456, p=0.020; 26.7% and 41.8% in patient and control groups, respectively) for 584 C/T. Even though the TT genotype was not significantly different, it had p=0.054 which supported our results. Conclusion: The endothelial lipase gene (584 C/T) T allele might be protective in association with coronary artery disease. Therefore, LIPG gene is related to risk for CAD in the Turkish population probably through altering HDL-C metabolism.