PT  - JOURNAL ARTICLE
AU  - CHRISTOS YAPIJAKIS
AU  - ZOE SEREFOGLOU
AU  - ALEXANDER M. NIXON
AU  - ANTONIS VYLLIOTIS
AU  - VASSILIS RAGOS
AU  - ELEFTHERIOS VAIRAKTARIS
TI  - Prevalence of Thrombosis-related DNA Polymorphisms in a Healthy Greek Population
DP  - 2012 Nov 01
TA  - In Vivo
PG  - 1095--1101
VI  - 26
IP  - 6
4099  - http://iv.iiarjournals.org/content/26/6/1095.short
4100  - http://iv.iiarjournals.org/content/26/6/1095.full
SO  - In Vivo2012 Nov 01; 26
AB  - Genetic association studies have revealed a correlation between DNA variations in genes encoding factors of the haemostatic system and thrombosis-related disease. This study investigated the prevalence of 13 such genetic risk factors in a sample (N=400 alleles) of the Hellenic population of Greece. Some of these polymorphisms [coagulation factor V (F5) Leiden, coagulation factor II (F2) G20210A, 5,10-methylene tetrahydrofolate reductase (MTHFR) C677T, coagulation factor XIII A1 subunit (F13A1) Val34Leu, serpine1 (SERPINE1) 4G/5G, angiotensin I-converting enzyme (ACE) I/D, angiotensinogen (AGT) Met325Thr, integrin A2 (ITGA2) C807T] have been previously studied in Hellenic populations of Greece and Cyprus, while others such as coagulation factor XII (F12) C46T, plasma carboxypeptidase B2 (CPB2) C1040T, platelet glycoprotein Ib α polypeptide (GP1BA) VNTR, thrombomodulin (THBD) -A33G and protein Z (PROZ) - A13G have not. Most of the allelic frequencies observed are similar to those reported for other Southern European populations. Knowledge of the prevalence of these variations in a given population may assist in the design of effective preventive measures against cardiovascular disease.