RT Journal Article
SR Electronic
T1 Regeneration of Mandibular Osteoradionecrosis Defect with Platelet Rich Plasma Gel
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 889
OP 893
VO 24
IS 6
A1 M. SCALA
A1 M. GIPPONI
A1 P. MEREU
A1 P. STRADA
A1 R. CORVÒ
A1 A. MURAGLIA
A1 M. MASSA
A1 S. BERTOGLIO
A1 P. SANTI
A1 F. CAFIERO
YR 2010
UL http://iv.iiarjournals.org/content/24/6/889.abstract
AB Osteoradionecrosis (ORN) of the mandible is a major complication of radiation therapy of head and neck cancer with a potential of occurrence ranging from 5 to 15% of the irradiated patients. Due to the gradual necrotic process, the mandibular bone becomes necrotic and looses its spontaneous regeneration ability. Containing an elevated content of mitogenic and osteogenic growth factors, the use of platelet rich plasma (PRP) from autologous source has been suggested to re-activate the healing process of osteogenesis. Autologous PRP gel was introduced into the ORN necrotic defect of a 44-year old patient previously treated for squamous cell carcinoma of the tongue, subsequent to proper surgical debridement. We report post-operative two-year follow-up demonstrated by panoramic X-ray which showed regain of the mandibular bone continuity with a complete repair of the necrotic defects. We conclude that this case illustrates an incident of successful regeneration of ORN critical-sized defect of the mandible by autologous PRP gel.