RT Journal Article
SR Electronic
T1 Comparison of the Degree of Hip Joint Luxation Induced by the Lateral and Medial Surgical Approaches Used to Generate Vascular Deprivation-induced Necrosis of the Femoral Head in Rats
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 821
OP 825
VO 24
IS 6
A1 JONG MIN KIM
A1 TAE SUNG HAN
A1 JINUK PARK
A1 BIBEK CHANDRA SUTRADHAR
A1 GONHYUNG KIM
A1 SEONG SOO KANG
A1 SEOK HWA CHOI
YR 2010
UL http://iv.iiarjournals.org/content/24/6/821.abstract
AB The rat model that is commonly used to study femoral head osteonecrosis involves the induction of osteonecrosis by surgery employing a lateral approach to the hip joint. However, this approach induces hip joint luxation, which means it is difficult to determine whether the osteonecrosis arises because of the vascular deprivation or because of the hip joint luxation. Whether or not femoral head osteonecrosis can be induced by the medial approach to the hip joint, which does not generate hip joint luxation, was assessed. Materials and Methods: Twelve 6-month-old F344 rats were subjected to the lateral or medial approach. Results: Four weeks after surgery, the lateral approach group showed luxation upon radiography, but the medial approach group did not. Histopathology revealed both groups exhibited osteonecrosis of the femoral head. Conclusion: A surgically induced model of femoral head osteonecrosis that employs the medial approach is a more effective model than that using the lateral approach.