RT Journal Article
SR Electronic
T1 The Impact of Ultrasound Contrast Medium Administration on the Right Ventricle in Patients with Heart Failure
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 869
OP 873
VO 26
IS 5
A1 DIMITRIOS BRAMOS
A1 ANNA KALADARIDOU
A1 ELIAS SKALTSIOTIS
A1 CHRISANTHI TRIKA
A1 DIMITRIOS TAKOS
A1 CONSTANTINOS PAMBOUCAS
A1 GEORGE KOTTIS
A1 SAVVAS TOUMANIDIS
YR 2012
UL http://iv.iiarjournals.org/content/26/5/869.abstract
AB Background: The purpose of the present study was to examine the effect of SonoVue™ on right ventricular (RV) dimensions and contractility in patients with heart failure. Patients and Methods: Twenty-four patients were divided into two groups. Group A consisted of 15 patients with heart failure and group B (control) of nine patients without heart disease. SonoVue was administered at low (2 ml) and high (4 ml) doses in both groups separately, in a random order. RV dimensions, contractility, peak systolic pressure gradient from tricuspid regurgitation (TRPG) and the time to maximal RV end-diastolic dimension (EDD), as well as the time for RV-EDD to return to the baseline value (recovery), were calculated in every cardiac cycle starting before the administration of SonoVue (baseline) until the recovery of RV-EDD. Results: Low-(group A, p<0.001 and group B, p<0.05) and high-dose (group A, p<0.0001 and group B, p<0.01) contrast infusion increased the RV-EDD compared to baseline values. TRPG increased significantly (p<0.05) in both groups, under low-as well as high-dose. In group A, high-dose compared to low-dose produced a significant delay in the time duration to max RV-EDD (p<0.05) and in the time to RV-EDD recovery (p<0.0001). Conclusion: The administration of SonoVue in patients with heart failure was followed by an acute, transient, dose-dependent increase in RV-EDD and TRPG, without any effect on RV contractility.