RT Journal Article
SR Electronic
T1 Mouse Models of Inflammatory Bowel Disease - Insights into the Mechanisms of Inflammation-associated Colorectal Cancer
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 627
OP 646
VO 26
IS 4
A1 DESSISLAVA MLADENOVA
A1 MAIJA R. J. KOHONEN-CORISH
YR 2012
UL http://iv.iiarjournals.org/content/26/4/627.abstract
AB The association between chronic inflammation and cancer has been noted for at least a century but the exact molecular mechanisms of cancer initiation and promotion by such inflammation are still poorly understood. The gastrointestinal tract is a unique organ where maintaining a balance between the colonic epithelial cells, the immune system and a fine-tuned response to the resident microflora is crucial for preserving the gut homeostasis. A breakdown of the tight interdependent regulation of the epithelium–immunity–microbiota triangle leads to inflammatory bowel disorders and may promote cancer. This review focuses on inflammation-associated colorectal cancer in mouse models of the disease and highlights emerging research trends.