%0 Journal Article %A DESSISLAVA MLADENOVA %A MAIJA R. J. KOHONEN-CORISH %T Mouse Models of Inflammatory Bowel Disease - Insights into the Mechanisms of Inflammation-associated Colorectal Cancer %D 2012 %J In Vivo %P 627-646 %V 26 %N 4 %X The association between chronic inflammation and cancer has been noted for at least a century but the exact molecular mechanisms of cancer initiation and promotion by such inflammation are still poorly understood. The gastrointestinal tract is a unique organ where maintaining a balance between the colonic epithelial cells, the immune system and a fine-tuned response to the resident microflora is crucial for preserving the gut homeostasis. A breakdown of the tight interdependent regulation of the epithelium–immunity–microbiota triangle leads to inflammatory bowel disorders and may promote cancer. This review focuses on inflammation-associated colorectal cancer in mouse models of the disease and highlights emerging research trends. %U https://iv.iiarjournals.org/content/invivo/26/4/627.full.pdf