TY - JOUR T1 - Association of Vitamin D Receptor Taq I Polymorphism and Susceptibility to Oral Squamous Cell Carcinoma JF - In Vivo JO - In Vivo SP - 755 LP - 759 VL - 24 IS - 5 AU - KIVANÇ BEKTAŞ-KAYHAN AU - MERAL ÜNÜR AU - İLHAN YAYLIM-ERALTAN AU - H.ARZU ERGEN AU - BAHAR TOPTAŞ AU - GÜNTER HAFIZ AU - AHMET KARADENIZ AU - TURGAY İSBIR Y1 - 2010/09/01 UR - http://iv.iiarjournals.org/content/24/5/755.abstract N2 - Background: It has been hypothesised that vitamin D receptor (VDR) gene polymorphisms may influence both the risk of cancer occurrence and prognosis. Materials and Methods: The distribution of VDR Taq I polymorphism in 64 patients with OSCC was determined by polymerase chain reaction based restriction fragment length polymorphism (RFLP) and compared with that of 87 healthy controls. Results: There was a significant difference in the distribution of VDR Taq I genotypes between OSCC patients and healthy controls. Patients with the VDR Tt genotype were found to be at significantly higher risk for OSCC than those with other genotypes (p=0.036). In particular, female OSCC patients were at higher risk (p<0.001) for oral cancer. Conclusion: These results suggest that the VDR Taq I polymorphism may be associated with susceptibility to OSCC. Female predilection of the OSCC risk in association with VDR gene polymorphism should also be investigated. ER -