RT Journal Article SR Electronic T1 Expanded Effector Memory T-lymphocytes in DBA/2 Mice Do Not Inhibit the Growth of SL2 Tumours JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 553 OP 557 VO 26 IS 4 A1 JURGITA JURŠĖNAITĖ A1 IRUTĖ GIRKONTAITĖ A1 MYKOLAS MAURICAS A1 RIMANTAS EIDUKEVIČIUS A1 DAINIUS CHARACIEJUS YR 2012 UL http://iv.iiarjournals.org/content/26/4/553.abstract AB Background: The aim of this study was to analyse changes in levels of memory T-lymphocytes during growth of SL2 tumours in DBA/2 mice and to evaluate whether these lymphocytes may have an inhibitory effect on tumour growth. Materials and Methods: Percentages of naïve (CD8+CD44lowCD62L+), central memory (CD8+CD44high CD62L+) and effector memory (CD8+CD44highCD62L−) lymphocytes in the CD8+ subset in peripheral blood, spleen and lymph nodes of tumour-bearing and control mice were analysed by flow cytometry. Results: The percentage of effector memory lymphocytes in the CD8+ subset increased during growth of tumours, whereas that of naïve CD8+ lymphocytes decreased. No correlation between the levels of effector memory lymphocytes in peripheral blood and the mass of tumours was found. Conclusion: SL2 tumours induce expansion of effector memory lymphocytes in DBA/2 mice. However, expanded effector memory lymphocytes do not inhibit the growth of tumours.