TY - JOUR T1 - Expanded Effector Memory T-lymphocytes in DBA/2 Mice Do Not Inhibit the Growth of SL2 Tumours JF - In Vivo JO - In Vivo SP - 553 LP - 557 VL - 26 IS - 4 AU - JURGITA JURŠĖNAITĖ AU - IRUTĖ GIRKONTAITĖ AU - MYKOLAS MAURICAS AU - RIMANTAS EIDUKEVIČIUS AU - DAINIUS CHARACIEJUS Y1 - 2012/07/01 UR - http://iv.iiarjournals.org/content/26/4/553.abstract N2 - Background: The aim of this study was to analyse changes in levels of memory T-lymphocytes during growth of SL2 tumours in DBA/2 mice and to evaluate whether these lymphocytes may have an inhibitory effect on tumour growth. Materials and Methods: Percentages of naïve (CD8+CD44lowCD62L+), central memory (CD8+CD44high CD62L+) and effector memory (CD8+CD44highCD62L−) lymphocytes in the CD8+ subset in peripheral blood, spleen and lymph nodes of tumour-bearing and control mice were analysed by flow cytometry. Results: The percentage of effector memory lymphocytes in the CD8+ subset increased during growth of tumours, whereas that of naïve CD8+ lymphocytes decreased. No correlation between the levels of effector memory lymphocytes in peripheral blood and the mass of tumours was found. Conclusion: SL2 tumours induce expansion of effector memory lymphocytes in DBA/2 mice. However, expanded effector memory lymphocytes do not inhibit the growth of tumours. ER -