TY - JOUR T1 - Metabolite Formation of 17α-Hydroxyprogesterone as a Consequence of e<sup>−</sup><sub>aq</sub>-Emission and Progesterone Effect Regarding Cancer JF - In Vivo JO - In Vivo SP - 727 LP - 733 VL - 24 IS - 5 AU - NIKOLA GETOFF AU - IREN DANIELOVA AU - JOHANNES HARTMANN AU - HEIKE SCHITTL AU - MARION GERSCHPACHER AU - SHAOBIN YING AU - RUTH QUINT AU - JOHANNES C. HUBER Y1 - 2010/09/01 UR - http://iv.iiarjournals.org/content/24/5/727.abstract N2 - Based on previous investigations on several hormones, 17α-hydroxyprogesterone (17α-HOPRG) was studied in respect to cancer initiation by its metabolites resulting from electron emission. The emission of electrons (e−aq) from its singlet excited state of 17α-HOPRG and HPLC-analysis of products were studied. Possible carcinogenicity of metabolites originating from 17α-HOPRG and the effect of progesterone (PRG) in this respect were studied in vitro. The results showed that 17α-HOPRG is very sensitive towards oxygen. The highest Q(e−aq) values were obtained by dissolution and UV-irradiation of substrate in airfree media. 17α-HOPRG metabolites showed a strong anticancer activity, which is, however, lower compared to that of PRG-metabolites. Mixture of both hormones, 17α-HOPRG and PRG, in respect to carcinogenicity showed a synergistic effect of PRG on 17α-HOPRG. Reaction mechanisms are presented. ER -