%0 Journal Article %A NIKOLA GETOFF %A IREN DANIELOVA %A JOHANNES HARTMANN %A HEIKE SCHITTL %A MARION GERSCHPACHER %A SHAOBIN YING %A RUTH QUINT %A JOHANNES C. HUBER %T Metabolite Formation of 17α-Hydroxyprogesterone as a Consequence of eaq-Emission and Progesterone Effect Regarding Cancer %D 2010 %J In Vivo %P 727-733 %V 24 %N 5 %X Based on previous investigations on several hormones, 17α-hydroxyprogesterone (17α-HOPRG) was studied in respect to cancer initiation by its metabolites resulting from electron emission. The emission of electrons (e−aq) from its singlet excited state of 17α-HOPRG and HPLC-analysis of products were studied. Possible carcinogenicity of metabolites originating from 17α-HOPRG and the effect of progesterone (PRG) in this respect were studied in vitro. The results showed that 17α-HOPRG is very sensitive towards oxygen. The highest Q(e−aq) values were obtained by dissolution and UV-irradiation of substrate in airfree media. 17α-HOPRG metabolites showed a strong anticancer activity, which is, however, lower compared to that of PRG-metabolites. Mixture of both hormones, 17α-HOPRG and PRG, in respect to carcinogenicity showed a synergistic effect of PRG on 17α-HOPRG. Reaction mechanisms are presented. %U https://iv.iiarjournals.org/content/invivo/24/5/727.full.pdf