PT  - JOURNAL ARTICLE
AU  - JOAQUÍN HERNÁNDEZ-GODOY
AU  - DOLORES PLANELLES SILVESTRE
AU  - BALTASAR BALSALOBRE HERNÁNDEZ
TI  - Immediate and Short-, Mid- and Long-term Effects of <em>In Vivo</em> Ionizing Radiation Exposure in BALB/c Mice: I. Activation of Lymphocytes and Subpopulations
DP  - 2010 Sep 01
TA  - In Vivo
PG  - 719--726
VI  - 24
IP  - 5
4099  - http://iv.iiarjournals.org/content/24/5/719.short
4100  - http://iv.iiarjournals.org/content/24/5/719.full
SO  - In Vivo2010 Sep 01; 24
AB  - Background: The main aim of this work was to study the effects of single whole-body irradiation (WBI) on the lymphoproliferative response in radiation-sensitive BALB/c mice. Materials and Methods: Mice were irradiated (0-5 Gy) and euthanized immediately afterward; other animals were subjected to WBI (4 Gy) and were analyzed after periods of 0-180 days. Splenic cell number, lymphoproliferative response and lymphocyte subpopulations were studied. Results: This study shows that immediately after exposure, an inhibition of the basal mitogen lymphoproliferative response was produced; furthermore, B-cells appear to be more radiosensitive than T-cells. However, up to 90 day's post-irradiation, mice spleens clearly show low cell numbers, and subpopulations and T-cell mitogens did not return to normal, while the basal response and B-cell mitogens peaked on day 15 post-WBI. Conclusion: In our model, B-cells regenerate earlier than T-cells, while Th lymphocytes regenerate faster than Tc lymphocytes.