PT  - JOURNAL ARTICLE
AU  - JULIANA NOGUTI
AU  - LUIS FERNANDO BARBISAN
AU  - AUGUSTO CESAR
AU  - CAMILO DIAS SEABRA
AU  - RODRIGO BRASIL CHOUERI
AU  - DANIEL ARAKI RIBEIRO
TI  - <em>In Vivo</em> Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis
DP  - 2012 Jul 01
TA  - In Vivo
PG  - 647--650
VI  - 26
IP  - 4
4099  - http://iv.iiarjournals.org/content/26/4/647.short
4100  - http://iv.iiarjournals.org/content/26/4/647.full
SO  - In Vivo2012 Jul 01; 26
AB  - The Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk.