PT  - JOURNAL ARTICLE
AU  - JAMES K. STOOPS
AU  - RANJANA ARORA
AU  - LISA ARMITAGE
AU  - AUDREY WANGER
AU  - LING SONG
AU  - MICHAEL R. BLACKBURN
AU  - GERHARD R. KRUEGER
AU  - SEMYON A. RISIN
TI  - Certain Surfactants Show Promise in the Therapy of Pulmonary Tuberculosis
DP  - 2010 Sep 01
TA  - In Vivo
PG  - 687--694
VI  - 24
IP  - 5
4099  - http://iv.iiarjournals.org/content/24/5/687.short
4100  - http://iv.iiarjournals.org/content/24/5/687.full
SO  - In Vivo2010 Sep 01; 24
AB  - Background/Aim: The aim of the present study was to develop the basis for the use of surfactants in the treatment of pulmonary tuberculosis (TB). Bacteria are surrounded by a thick lipid coat primarily consisting of trehalose dimycolate (TDM) and, consequently, are well shielded from the immune system's response and antibiotics. This protective barrier was removed by exposing the bacteria to certain surfactants. Materials and Methods: Dodecyl maltoside (DDM) and octyl glucoside (OG) were utilized as non-toxic surfactants. Results: Electron microscopy (EM) studies revealed that aggregated bacteria were also covered with excessive TDM which exacerbate the treatment efforts. Light and EM studies demonstrated that DDM and OG disperse the aggregated bacteria and are bactericidal. Conclusion: The studies presented here establish that certain surfactants are proficient in removing MTB's shield and, because they are well known as cell permeabilizing agents, they may also enhance the effectiveness of antibiotics and the immune system's response in the treatment of pulmonary TB.