RT Journal Article
SR Electronic
T1 Scintigraphic Assessment of Salivary Gland Function in a Rat Model
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 681
OP 685
VO 24
IS 5
A1 ANDREAS PFESTROFF
A1 FELIX MÜLLER
A1 DAMIANO LIBRIZZI
A1 BEHFAR EIVAZI
A1 MARTIN BEHE
A1 HELMUT HOEFFKEN
A1 THOMAS M. BEHR
A1 AFSHIN TEYMOORTASH
YR 2010
UL http://iv.iiarjournals.org/content/24/5/681.abstract
AB Background: Salivary gland dysfunction with xerostomia is a major clinical problem without a causal therapy in most cases. The development of an animal model for scintigraphic assessment of salivary gland function has great clinical relevance for the investigation of promising new diagnostic and therapeutic strategies for chronic salivary gland diseases. This study reports the first experiences with scintigraphic analyses of salivary gland function in a rat model. Materials and Methods: Anatomical and scintigraphic studies were performed for topographic differentiation of major salivary glands of Wistar rats. 99mtechnetium pertechnetate salivary gland scanning was performed, appropriate regions of interest were determined and the gland-to-background ratio was examined for the evaluation of salivary gland function. Results: The quantitative analysis of salivary gland scintigraphy revealed a reliable comparison of major salivary glands on both sides with the gland-to-background ratio ranging from 1.26 to 1.94 with an average of 1.51. Conclusion: This model seems to be appropriate for functional studies in an experimental setting.