RT Journal Article
SR Electronic
T1 Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 707
OP 715
DO 10.21873/invivo.11529
VO 33
IS 3
A1 JUNG, YUN-CHAN
A1 KIM, HYUN WOO
A1 MIN, BOK KEE
A1 CHO, JAE YOUNG
A1 SON, HYO JEONG
A1 LEE, JA YOUNG
A1 KIM, JI-YOUNG
A1 KWON, SAE-BOM
A1 LI, QIANG
A1 LEE, HEE-WOO
YR 2019
UL http://iv.iiarjournals.org/content/33/3/707.abstract
AB Background/Aim: The rapid increase in the number of people who are overweight or obese, which increases the risk of diseases and health problems, is becoming an important issue. Herein, we investigated whether olive leaf extract (OLE) has potent anti-obesity effects in high-fat induced mouse models. Materials and Methods: C57BL/6 mice were randomized into normal control, high-fat diet (HFD), HFD with OLE, and HFD with garcinia groups and administered experimental diets for 12 weeks. Body weight and food intake were measured once per week and obesity-related biomarkers were evaluated in the serum and adipose tissue. Results: OLE significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice. Furthermore, the expression of adipogenesis- and thermogenesis-related molecules was decreased in the OLE-treated group. Conclusion: OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis.