RT Journal Article SR Electronic T1 Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 707 OP 715 DO 10.21873/invivo.11529 VO 33 IS 3 A1 YUN-CHAN JUNG A1 HYUN WOO KIM A1 BOK KEE MIN A1 JAE YOUNG CHO A1 HYO JEONG SON A1 JA YOUNG LEE A1 JI-YOUNG KIM A1 SAE-BOM KWON A1 QIANG LI A1 HEE-WOO LEE YR 2019 UL http://iv.iiarjournals.org/content/33/3/707.abstract AB Background/Aim: The rapid increase in the number of people who are overweight or obese, which increases the risk of diseases and health problems, is becoming an important issue. Herein, we investigated whether olive leaf extract (OLE) has potent anti-obesity effects in high-fat induced mouse models. Materials and Methods: C57BL/6 mice were randomized into normal control, high-fat diet (HFD), HFD with OLE, and HFD with garcinia groups and administered experimental diets for 12 weeks. Body weight and food intake were measured once per week and obesity-related biomarkers were evaluated in the serum and adipose tissue. Results: OLE significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice. Furthermore, the expression of adipogenesis- and thermogenesis-related molecules was decreased in the OLE-treated group. Conclusion: OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis.