TY - JOUR T1 - Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice JF - In Vivo JO - In Vivo SP - 707 LP - 715 DO - 10.21873/invivo.11529 VL - 33 IS - 3 AU - YUN-CHAN JUNG AU - HYUN WOO KIM AU - BOK KEE MIN AU - JAE YOUNG CHO AU - HYO JEONG SON AU - JA YOUNG LEE AU - JI-YOUNG KIM AU - SAE-BOM KWON AU - QIANG LI AU - HEE-WOO LEE Y1 - 2019/05/01 UR - http://iv.iiarjournals.org/content/33/3/707.abstract N2 - Background/Aim: The rapid increase in the number of people who are overweight or obese, which increases the risk of diseases and health problems, is becoming an important issue. Herein, we investigated whether olive leaf extract (OLE) has potent anti-obesity effects in high-fat induced mouse models. Materials and Methods: C57BL/6 mice were randomized into normal control, high-fat diet (HFD), HFD with OLE, and HFD with garcinia groups and administered experimental diets for 12 weeks. Body weight and food intake were measured once per week and obesity-related biomarkers were evaluated in the serum and adipose tissue. Results: OLE significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice. Furthermore, the expression of adipogenesis- and thermogenesis-related molecules was decreased in the OLE-treated group. Conclusion: OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis. ER -